Finally submitted! 🎉 We are excited to soon share our research on how genetics contribute to medication discontinuation in ADHD.
Stimulant medications are the first-line treatment for ADHD, but over 50% of individuals discontinue them within two years. Our study, involving 18,362 individuals from the iPSYCH cohort, aimed to uncover the genetic factors behind this.
Key findings:
- No genome-wide significant loci were identified.
- Potential genetic differences in discontinuation between children and adults.
- Higher polygenic risk scores (PRS) for psychiatric disorders linked to increased discontinuation.
- Adults showed a higher SNP-heritability for discontinuation compared to children.
- Rare deleterious variants in dopamine-related genes were less common in those who discontinued medication, especially in adults.
Our results suggest that genetics may play a slightly stronger role in medication discontinuation in adults compared to children. Stay tuned for more insights and check out the abstract here: https://www.sciencedirect.com/science/article/abs/pii/S0924977X24003390
This post was provided by Isabell Brikell.